Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
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منابع مشابه
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain.
Cholesterol 24-hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the majority of cholesterol turnover in the central nervous system. Mice deficient in 24-hydroxylase exhibit impaired learning and defective hippocampal long-term potentiation, suggesting that the metabolism of cholesterol by this enzyme is required for learning and memory...
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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma. To gain molecular insight into this pathway of cholesterol metabolism, we used expression cloning to isolate cDNAs that encode murine and human cholesterol 24-hydroxylases. DNA sequen...
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ژورنال
عنوان ژورنال: The Journal of Comparative Neurology
سال: 2008
ISSN: 0021-9967,1096-9861
DOI: 10.1002/cne.21605